rac-2-[(2-Chlorophenyl)(4-chlorophenyl)methyl]-1,3-dioxolane
نویسندگان
چکیده
The title compound, C(16)H(14)Cl(2)O(2), is a chiral mitotane derivative that contains a dioxolane ring and crystallizes from methanol as a racemic mixture. It was obtained in high yield from mitotane and ethyl-eneglycol in alkaline medium, followed by neutralization with sulfuric acid and extraction with ethyl acetate. The mol-ecular structure is stabilized by an intra-molecular C- H⋯ O hydrogen bond. The dihedral angle between the aromatic rings is 80.1 (2)°. The dioxolane ring adopts a puckered envelope conformation with an O atom as the flap.
منابع مشابه
(4S,5S)-2-(4-Chlorophenyl)-1,3-dioxolane-4,5-dicarboxamide
The title compound, C(11)H(11)ClN(2)O(4), is an important inter-mediate for the preparation of platinum anti-cancer drugs. The dioxolane ring adopts a twist conformation with an equatorially attached chloro-phenyl substituent. In the crystal structure, mol-ecules are linked into a two-dimensional network parallel to (001) by N-H⋯O and C-H⋯O hydrogen bonds.
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